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Popular Diabetes Drugs May Reduce The Risk Of Dementia


Popular Diabetes Drugs May Reduce The Risk Of Dementia

Alzheimer's dementia

People with type 2 diabetes who are treated with GLP-1 agonists have a decreased risk of developing dementia, according to a new study from Karolinska Institutet in Sweden published in the journal eClinicalMedicine.

Drugs known as GLP-1 agonists or GLP-1 analogues have become increasingly popular in treating type 2 diabetes and obesity as they help control blood sugar, promote weight loss and protect the heart.

People with type 2 diabetes have an increased risk of developing dementia and it’s been hypothesised that newer diabetes drugs such as GLP-1 agonists and DPP-4 inhibitors might have a protective effect.

In the new register-based study, researchers followed more than 88,000 older individuals with type 2 diabetes for up to ten years. Using a study design called target trial emulation, which imitates a randomised clinical trial, they analysed the association between three diabetes drugs (GLP-1 agonists, DPP-4 inhibitors or sulfonylureas) and the risk of dementia.

They found that patients who used GLP-1 agonists had a 30 per cent lower risk of developing dementia compared to those who used sulfonylureas, and a 23 per cent lower risk compared to those who used DPP-4 inhibitors.

“This is important because it can help doctors make better decisions about which medicines to use for older patients with type 2 diabetes,” says lead author Bowen Tang, a PhD student in Sara Hägg’s research group at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet. “However, proper randomised trials are needed to establish with certainty that GLP-1 agonists reduce the risk of dementia.”

The study was funded by the Swedish Research Council, Karolinska Institutet, the National Institute on Aging, the National Institutes of Health, and Riksbankens Jubileumsfond. There are no reported conflicts of interest.


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South Caucasus News

Iron Meteorites Hint That Infant Solar System Was More Doughnut Than Dartboard


Iron Meteorites Hint That Infant Solar System Was More Doughnut Than Dartboard

meteorite asteroid

Four and a half billion years ago, our solar system was a cloud of gas and dust swirling around the sun, until gas began to condense and accrete along with dust to form asteroids and planets. What did this cosmic nursery, known as a protoplanetary disk, look like, and how was it structured? Astronomers can use telescopes to “see” protoplanetary disks far away from our much more mature solar system, but it is impossible to observe what ours might have looked like in its infancy — only an alien billions of light years away would be able to see it as it once was.

Fortunately, space has dropped a few clues — fragments of objects that formed early in solar system history and plunged through Earth’s atmosphere, called meteorites. The composition of meteorites tells stories of the solar system’s birth, but these stories often raise more questions than answers.

In a paper published in Proceedings of the National Academy of Sciences, a team of planetary scientists from UCLA and Johns Hopkins University Applied Physics Laboratory reports that refractory metals, which condense at high temperatures, such as iridium and platinum, were more abundant in meteorites formed in the outer disk, which was cold and far away from the sun. These metals should have formed close to the sun, where the temperature was much higher. Was there a pathway that moved these metals from the inner disk to the outer?

Most meteorites formed within the first few million years of solar system history. Some meteorites, called chondrites, are unmelted conglomerations of grains and dust left over from planet formation. Other meteorites experienced enough heat to melt while their parent asteroids were forming. When these asteroids melted, the silicate part and the metallic part separated due to their difference in density, similar to how water and oil don’t mix.

Today, most asteroids are located in a thick belt between Mars and Jupiter. Scientists think that Jupiter’s gravity disrupted the course of these asteroids, causing many of them to smash into each other and break apart. When pieces of these asteroids fall to Earth and are recovered, they are called meteorites.

Iron meteorites are from the metallic cores of the earliest asteroids, older than any other rocks or celestial objects in our solar system. The irons contain molybdenum isotopes that point toward many different locations across the protoplanetary disk in which these meteorites formed. That allows scientists to learn what the chemical composition of the disk was like in its infancy.

Previous research using the Atacama Large Millimeter/submillimeter Array in Chile has found many disks around other stars that resemble concentric rings, like a dartboard. The rings of these planetary disks, such as HL Tau, are separated by physical gaps, so this kind of disk could not provide a route to transport these refractory metals from the inner disk to the outer.

The new paper holds that our solar disk likely didn’t have a ring structure at the very beginning. Instead, our planetary disk looked more like a doughnut, and asteroids with metal grains rich in iridium and platinum metals migrated to the outer disk as it rapidly expanded.

But that confronted the researchers with another puzzle. After the disk expansion, gravity should have pulled these metals back into the sun. But that did not happen.

“Once Jupiter formed, it very likely opened a physical gap that trapped the iridium and platinum metals in the outer disk and prevented them from falling into the sun,” said first author Bidong Zhang, a UCLA planetary scientist. “These metals were later incorporated into asteroids that formed in the outer disk. This explains why meteorites formed in the outer disk – carbonaceous chondrites and carbonaceous-type iron meteorites – have much higher iridium and platinum contents than their inner-disk peers.”

Zhang and his collaborators previously used iron meteorites to reconstruct how water was distributed in the protoplanetary disk.

“Iron meteorites are hidden gems. The more we learn about iron meteorites, the more they unravel the mystery of our solar system’s birth,” Zhang said.


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South Caucasus News

Moderate candidate in Iran criticizes headscarf policy – Yahoo! Voices


Moderate candidate in Iran criticizes headscarf policy  Yahoo! Voices

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Audio Review - South Caucasus News

US prosecutors recommend Justice Department criminally charge Boeing as deadline looms


Washington — U.S. prosecutors are recommending to senior Justice Department officials that criminal charges be brought against Boeing after finding the planemaker violated a settlement related to two fatal crashes, two people familiar with the matter told Reuters.

The Justice Department (DOJ) must decide by July 7 whether to prosecute Boeing. The recommendation of prosecutors handling the case has not been previously reported.

In May, officials determined the company breached a 2021 agreement that had shielded Boeing from a criminal charge of conspiracy to commit fraud arising from two fatal crashes in 2018 and 2019 involving the 737 MAX jet.

Under the 2021 deal, the Justice Department agreed not to prosecute Boeing over allegations it defrauded the Federal Aviation Administration so long as the company overhauled its compliance practices and submitted regular reports. Boeing also agreed to pay $2.5 billion to settle the investigation.

Boeing declined to comment. It has previously said it has “honored the terms” of the 2021 settlement, which had a three-year term and is known as a deferred prosecution agreement. Boeing has told the Justice Department it disagrees with its determination that the company violated the settlement, Reuters reported this month.

A spokesperson for the Justice Department declined to comment.

The two sides are in discussions over a potential resolution to the Justice Department’s investigation and there is no guarantee officials will move forward with charges, the two sources said. The internal Justice Department deliberations remain ongoing, and no final decisions have been reached, they added.

Criminal charges would deepen an unfolding crisis at Boeing, which has faced intense scrutiny from U.S. prosecutors, regulators and lawmakers after a panel blew off one of its jets operated by Alaska Airlines mid-flight Jan. 5, just two days before the 2021 settlement expired.

The sources did not specify what criminal charges Justice Department officials are considering, but one of the people said they could extend beyond the original 2021 fraud conspiracy charge.

Alternatively, instead of prosecuting Boeing, the DOJ could extend the 2021 settlement by a year or propose new, stricter terms, the sources said.

In addition to financial penalties, the strictest settlements typically involve installing a third party to monitor a company’s compliance. The DOJ can also require the company to admit its wrongdoing by pleading guilty.

Boeing may be willing to pay a penalty and agree to a monitor, but believes a guilty plea, which typically incurs additional business restrictions, could be too damaging, said one of the sources. Boeing derives significant revenue from contracts with the U.S. government, including the Defense Department, which could be jeopardized by a felony conviction, one of the sources said.

Relatives of the victims of the two fatal 737 MAX crashes have long criticized the 2021 agreement, arguing that Justice Department officials should have prosecuted the company and its executives.

At a Senate hearing in June, Chief Executive Dave Calhoun acknowledged the company’s shortcomings on safety and apologized to the families who lost loved ones.

Last week, the families pressed prosecutors to seek a fine against the planemaker of nearly $25 billion and move forward with a criminal prosecution.


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South Caucasus News

US prosecutors recommend Justice Department criminally charge Boeing as deadline looms


Washington — U.S. prosecutors are recommending to senior Justice Department officials that criminal charges be brought against Boeing after finding the planemaker violated a settlement related to two fatal crashes, two people familiar with the matter told Reuters.

The Justice Department (DOJ) must decide by July 7 whether to prosecute Boeing. The recommendation of prosecutors handling the case has not been previously reported.

In May, officials determined the company breached a 2021 agreement that had shielded Boeing from a criminal charge of conspiracy to commit fraud arising from two fatal crashes in 2018 and 2019 involving the 737 MAX jet.

Under the 2021 deal, the Justice Department agreed not to prosecute Boeing over allegations it defrauded the Federal Aviation Administration so long as the company overhauled its compliance practices and submitted regular reports. Boeing also agreed to pay $2.5 billion to settle the investigation.

Boeing declined to comment. It has previously said it has “honored the terms” of the 2021 settlement, which had a three-year term and is known as a deferred prosecution agreement. Boeing has told the Justice Department it disagrees with its determination that the company violated the settlement, Reuters reported this month.

A spokesperson for the Justice Department declined to comment.

The two sides are in discussions over a potential resolution to the Justice Department’s investigation and there is no guarantee officials will move forward with charges, the two sources said. The internal Justice Department deliberations remain ongoing, and no final decisions have been reached, they added.

Criminal charges would deepen an unfolding crisis at Boeing, which has faced intense scrutiny from U.S. prosecutors, regulators and lawmakers after a panel blew off one of its jets operated by Alaska Airlines mid-flight Jan. 5, just two days before the 2021 settlement expired.

The sources did not specify what criminal charges Justice Department officials are considering, but one of the people said they could extend beyond the original 2021 fraud conspiracy charge.

Alternatively, instead of prosecuting Boeing, the DOJ could extend the 2021 settlement by a year or propose new, stricter terms, the sources said.

In addition to financial penalties, the strictest settlements typically involve installing a third party to monitor a company’s compliance. The DOJ can also require the company to admit its wrongdoing by pleading guilty.

Boeing may be willing to pay a penalty and agree to a monitor, but believes a guilty plea, which typically incurs additional business restrictions, could be too damaging, said one of the sources. Boeing derives significant revenue from contracts with the U.S. government, including the Defense Department, which could be jeopardized by a felony conviction, one of the sources said.

Relatives of the victims of the two fatal 737 MAX crashes have long criticized the 2021 agreement, arguing that Justice Department officials should have prosecuted the company and its executives.

At a Senate hearing in June, Chief Executive Dave Calhoun acknowledged the company’s shortcomings on safety and apologized to the families who lost loved ones.

Last week, the families pressed prosecutors to seek a fine against the planemaker of nearly $25 billion and move forward with a criminal prosecution.


Categories
South Caucasus News

Boosting vaccine storage, transportation, handling, and management in Azerbaijan – World Health Organization (WHO)


Boosting vaccine storage, transportation, handling, and management in Azerbaijan  World Health Organization (WHO)

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South Caucasus News

NPR News: 06-23-2024 6PM EDT


NPR News: 06-23-2024 6PM EDT

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South Caucasus News

Three dead after gunmen open fire at synagogue in Dagestan in Russia – MSN


Three dead after gunmen open fire at synagogue in Dagestan in Russia  MSN

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South Caucasus News

Iran-Backed Houthis Target 2 Ships In Red Sea, Indian Ocean – NDTV


Iran-Backed Houthis Target 2 Ships In Red Sea, Indian Ocean  NDTV

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South Caucasus News

Azerbaijan represented at OSCE high-level conference on climate change – Trend News Agency


Azerbaijan represented at OSCE high-level conference on climate change  Trend News Agency